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Working model of the engineered exosomes.
Exosomes are engineered with Lamp2b-HuR fusion protein in the donor cells. The exosomes are further acidified to remove the endogenous cargo. The exosomes are efficiently endocytosed by the macrophages in liver, spleen, etc. In the recipient cells, Lamp2b-HuR, as a surface protein on the endosome, drives the target RNAs of HuR to degradation when endosomes fused with the lysosomes.
