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. 2020 May 31;9(1):1769373. doi: 10.1080/20013078.2020.1769373

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Graphical abstract. (a) Metastatic oral cancer cells secreted HSP90-high EVs transmitting to recipient cells. Metastatic oral cancer-EVs initiated EMT in normal epithelial cells and promoted migration, invasion, and tumorigenesis in oral cancer cells and M2-like polarity in tumour-associated macrophages. (b) The siRNAs-mediated triple silencing of CDC37/HSP90α/HSP90β diminished EMT markers in oral cancer cells. The HSP90-depleted EVs-reduced activities for transmission and pro-malignancy in recipient cells.