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. Author manuscript; available in PMC: 2021 Mar 8.
Published in final edited form as: Sci Signal. 2020 Sep 8;13(648):eabb2490. doi: 10.1126/scisignal.abb2490

Figure 2. Classification of metabolites based on the impact of diet or/and temperature.

Figure 2.

(a) Classification of metabolites according to their computational calculated trend during calorie restriction. DD: Diet-dependent. TD: Temperature-dependent. DTD: Diet- and temperature-dependent. (b) Total number of metabolites altered due to diet, temperature or both in plasma and the hypothalamus. (c-d) Number of metabolites changed due to food deprivation, temperature or both by metabolite class in plasma (c) and the hypothalamus (d). Size of circles is proportional to the total number of metabolites of each class. (e-h) Hierarchical clustering of metabolites sorted in different classes: Diet-dependent in plasma (e) and the hypothalamus (f) and temperature-dependent in plasma (g) and the hypothalamus (h).