Table 3.
Associations Between Genetic Risk Scores or Single-Nucleotide Variants of Sex Hormones and the Risk of EAC and BE
| EAC | BE | EAC/BE | |||
|---|---|---|---|---|---|
| Sex | Hormone | Missinga | OR (95% CI)b | OR (95% CI)b | OR (95% CI)b |
| Single-nucleotide variants | |||||
| Male | Follicle-stimulating hormone | 3 | 1.17 (1.03-1.34) | 1.12 (0.99-1.27) | 1.14 (1.01-1.27) |
| Female | Follicle-stimulating hormone | 0 | 1.29 (0.96-1.73) | 1.26 (1.00-1.59) | 1.28 (1.03-1.59) |
| Male | Estradiol | 101 | 1.23 (0.69-2.18) | 0.74 (0.40-1.35) | 0.95 (0.57-1.60) |
| Female | Estradiol | 29 | 0.28 (0.03-2.43) | 0.49 (0.14-1.68) | 0.42 (0.13-1.35) |
| Male | Free androgen index | 73 | 1.09 (0.91-1.31) | 1.08 (0.90-1.29) | 1.09 (0.93-1.28) |
| Female | Free androgen index | 20 | 0.82 (0.52-1.30) | 0.74 (0.52-1.05) | 0.78 (0.56-1.08) |
| Genetic risk scores | |||||
| Male | Luteinizing hormone | 91 | 0.92 (0.87-0.99) | 0.99 (0.93-1.06) | 0.96 (0.91-1.02) |
| Female | Luteinizing hormone | 22 | 0.93 (0.79-1.09) | 0.88 (0.77-0.99) | 0.89 (0.79-1.00) |
| Male | Sex hormone-binding globulin | 171 | 0.96 (0.91-1.04) | 0.99 (0.93-1.05) | 0.98 (0.93-1.04) |
| Male | Sex hormone-binding globulinc | 102 | 0.97 (0.91-1.04) | 1.00 (0.94-1.07) | 0.99 (0.94-1.05) |
| Female | Sex hormone-binding globulin | 14 | 1.04 (0.89-1.21) | 0.97 (0.86-1.09) | 0.99 (0.89-1.11) |
| Female | Sex hormone-binding globulinc | 0 | 0.97 (0.84-1.13) | 1.00 (0.90-1.13) | 1.00 (0.90-1.12) |
| Male | Dehydroepiandrosterone sulfate | 81 | 0.98 (0.92-1.05) | 0.98 (0.92-1.05) | 0.98 (0.92-1.04) |
| Female | Dehydroepiandrosterone sulfate | 24 | 1.15 (0.97-1.36) | 0.98 (0.88-1.11) | 1.02 (0.91-1.14) |
| Male | Progesterone | 72 | 0.99 (0.93-1.06) | 0.97 (0.91-1.04) | 0.98 (0.92-1.04) |
| Female | Progesterone | 19 | 0.95 (0.81-1.11) | 0.97 (0.86-1.09) | 0.96 (0.86-1.07) |
| Male | Testosterone | 89 | 0.95 (0.89-1.02) | 0.97 (0.91-1.03) | 0.96 (0.91-1.02) |
| Male | Testosteronec | 20 | 0.97 (0.90-1.03) | 0.99 (0.93-1.06) | 0.98 (0.92-1.04) |
| Male | Dihydrotestosterone | 129 | 1.03 (0.97-1.10) | 0.97 (0.91-1.04) | 1.00 (0.95-1.06) |
BE, Barrett’s esophagus; EAC, esophageal adenocarcinoma; OR, odds ratio.
a
Number of missing values of genetic risk score or single-nucleotide variant.
b
ORs (95% CIs) of per allele increase in estradiol, follicle-stimulating hormone, and free androgen index and ORs of per SD increase in genetic risk score forthe remaining, adjusted for age (continuous) and the first 4 genetic principal components.
c
Excluding SNPs rs12150660 and rs727428.