Skip to main content
. 2020 Oct 22;16(10):e1008876. doi: 10.1371/journal.ppat.1008876

Fig 2. Alphavirus attachment factors entry receptors.

Fig 2

Alphaviruses utilize several cell surface molecules including HS, DC-SIGN/L-SIGN, and PS receptors to carry out an initial attachment to target cells. These molecules increase infectivity of multiple alphaviruses and may also enhance virus internalization. Alphavirus receptors that satisfy all criteria to describe a protein as a virus receptor include NRAMP2 and Mxra8. Other putative receptors requiring further corroboration include laminin receptor and PHB1. CHIKV, Chikungunya; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; EEEV, Eastern equine encephalitis virus; HS, heparan sulfate; L-SIGN, liver-specific SIGN; MAYV, Mayaro; Mxra8, matrix remodeling associated protein 8; NRAMP2, natural resistance-associated macrophage protein 2; ONNV, O'nyong-nyong; PHB1, prohibitin1; PS, phosphatidylserine; RRV, Ross River; SFV, Semliki Forest; SINV, Sindbis; TIM-1, T cell immunoglobulin mucin domain 1.