TABLE 1.
P. falciparum genes upregulated in the mosquito stage
| Gene name | Gene ID | Product description | No. of variant codons in American strainsa | Upregulation (fold) in stageb
|
||
|---|---|---|---|---|---|---|
| Gametocyte V | Ookinete | Sporozoite | ||||
| TRAP | PF3D7_1335900 | Thrombospondin-related anonymous protein | 7 | 0 | 0 | 3,235.7 |
| CTRP | PF3D7_0315200 | Circumsporozoite- and TRAP-related protein | 5 | 0 | 582.1 | 0 |
| PSOP26 | PF3D7_1244500 | Conserved Plasmodium protein, unknown function | 5 | 0 | 133 | 0 |
| P47 | PF3D7_1346800 | 6-cysteine protein | 5 | 37.6 | 27.8 | 0 |
| NA | PF3D7_0511400 | Conserved Plasmodium protein, unknown function | 2 | 0 | 0 | 147.4 |
| SIAP1 | PF3D7_0408600 | Sporozoite invasion-associated protein 1 | 1 | 0 | 0 | 270.7 |
| NA | PF3D7_0515500 | Amino acid transporter, putative | 1 | 27.2 | 0 | 0 |
| PBLP | PF3D7_0818600 | BEM46-like protein, putative | 1 | 0 | 0 | 33.4 |
| CRMP1 | PF3D7_0911300 | Cysteine repeat modular protein 1 | 1 | 0 | 0 | 14 |
| ICP | PF3D7_0911900 | Falstatin | 1 | 0 | 0 | 11.4 |
| NA | PF3D7_0924600 | Conserved Plasmodium protein, unknown function | 1 | 29.4 | 19.8 | 0 |
| NA | PF3D7_1020200 | Conserved Plasmodium protein, unknown function | 1 | 86.5 | 223.6 | 0 |
| CRMP3 | PF3D7_1208200 | Cysteine repeat modular protein 3 | 1 | 0 | 0 | 16.8 |
| P48/45 | PF3D7_1346700 | 6-cysteine protein | 1 | 25 | 15.8 | 0 |
| NA | PF3D7_1348400 | Conserved Plasmodium membrane protein, unknown function | 1 | 20 | 0 | 0 |
| NA | PF3D7_1403200 | Conserved Plasmodium protein, unknown function | 1 | 158.9 | 82.1 | 0 |
| SOAP | PF3D7_1404300 | Secreted ookinete adhesive protein, putative | 1 | 0 | 70.8 | 0 |
a
Variant codons which have ≥0.7 frequency in America and ≤0.3 frequency in Africa.
b
Determined by comparison to blood stages.