Figure 2. Expression of CYP4Z1 in benign, malignant and metastatic tumours. (A) Distinct CYP4Z1 labelling can be seen in the cell cytoplasm in breast adenoma. Several malignant primary tumours displayed CYP4Z1 expression, including carcinomas of adrenal cortex (B), squamous cells of oesophagus, lung and cervix (C, D and E, respectively), seminoma (F), astrocytoma (G), melanoma (H) and lastly adenocarcinomas of breast, ovary, colon, prostate and endometrium (I, J, K, L and M, respectively). CYP4Z1 immunoreactivity was also demonstrated in metastatic tissues of the lymph node (N) and ovary (O) that have been originally derived from primary carcinomas of breast and colon, respectively. Magnification (×400).