Table 3.

Mechanisms of circRNAs regulation in viral replication and related disease.

CircRNA	Effect on virus	Regulated pathway	Refer-ence
circ_0000479	Overexpression promotes the expression of RIG-I and hampering HTNV replication	circ_0000479/ miR-149-5p/ RIG-I pathway	(Lu et al., 2020)
hsa_circ_0004812	Knockdown expression promotes the IFN-α/β, and inhibits HBV replication.	circ_0004812/ miR-1287-5p/ FSTL1 axis to regulate IFN-induced immune response	(Zhang and Wang, 2020)
circRNA_100338	Overexpression enhanced migratory and invasive ability of cancer cells	circRNA_100338 / miR-1413p axis to regulate invasive potential in liver cancer cells	(Huang et al., 2017)
circ-GATAD2A	Knockdown expression enhances autophagy and inhibits IAV H1N1 replication, reverse after overexpression	circ-GATAD2A/ VPS34-dependent autophagy pathway	(Yu et al., 2019)
circ-Vav3	Overexpression induces EMT, promote ALV-J related tumorigenesis	circ-Vav3/gga-miR-375/YAP1 axis induces EMT pathway	(Zhang et al., 2019)
circEZH2	Overexpression inhibits TGEV-induced mPTP opening and regulate NF-κB activation	circEZH2/ miR-22/ HK2 axis, circEZH2 /miR-22/IL-6/ NF-Kb pathway to regulate mPTP opening	(Zhao et al., 2019b)