Fig. 4.

SARS-CoV-2 Interacting Proteins that are Upregulated in Different Placental Cell Lines. Fig. 4a and c shows genes upregulated in HTR-8/SVneo and SGHPL5 cells, respectively, in comparison with JEG3 cells (Fig. 4b and d). The dataset used was GSE20510. Fig. 4e shows combined analysis of datasets GSE20510 and GSE28551 involving genes that are upregulated in first trimester placenta and surrogates used in vitro studies for first-trimester placenta – HTR8/SVneo and SGHPL-5 cell lines, and the human SARS-CoV-2 interactome. STRING (Fig. 4f) and GeneMANIA (Fig. 4g) analysis show TLE3 interacting proteins. The expansions of all the gene names are given in Supplementary Table 2.