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. 2020 Oct 22;114:77–78. doi: 10.1016/j.pediatrneurol.2020.10.005

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A hematoxylin and eosin pathology slide showing an infiltrate of mononuclear inflammatory cells around a cortical blood vessel (A). The surrounding cortex is edematous, and the neurons are hyperchromatic. Immunostains for CD 3, a T cell lymphocyte marker (B), and CD 163, a histiocyte marker (C), show a mixed inflammatory infiltrate consisting of T cells and histiocytes within both the meninges and cerebral cortex. An electron micrograph reveals vesiculo-vacuolar organelles within the cerebral endothelial cells with no evidence of virions (D). Immunostains for CD20, a B cell marker, showed only rare B cells.