Figure 1.

Efficacy of Inhaled Ifng against Experimental TB in Mice

(A) Mice were infected with Mtb by whole-body exposure in a Glas-Col chamber on day 0 and treated once a week starting at day 28. Two untreated control animals were culled on days 0, 28, and 56. Two treated animals were culled on days 28, 35, 42, and 56. Lungs and spleens were harvested as indicated by arrows. (B) Dashed line connecting open circles (○) show average ± standard error of mean (n=2) of log₁₀–transformed values of CFU/g of lung, and open squares (□) show these values in respect of the spleens. Filled symbols connected by solid lines starting from day 28 indicate CFU counts in these tissues in treated animals.