Figure 5.

Pharmacokinetics of IFN-γ in Uninfected and Infected Mice

(A–C) Scatter points show values from individual animals (A–C, uninfected mice, n = 3; D, infected mice, n = 2); points with error bars indicate mean ± SEM, and solid lines depict model-fitted values of concentrations of IFN-γ as determined by ELISA in BAL fluid (A), lung homogenate (B), and blood plasma (C) of uninfected mice. (D) The concentration-time profile in the BAL fluid of infected mice showing drastic shift in C_max and t_max (note the logarithmic scale of the y axis; see also Table S1).