Table 3. Pooled accuracy/sensitivity/specificity/PPV/NPV of techniques.
Accuracy | Sensitivity | Specificity | PPV | NPV | |
CS | 79.7 % (72.2–85.6) I 2 = 86; 8 studies | 79.2 % (70.7–85.7) I 2 = 89; 8 studies | 99.4 % (98.4–99.8) I 2 = 0; 7 studies | 99.5 % (98.5–99.8) I 2 = 0; 6 studies | 46.2 % (27.2–66.4) I 2 = 96; 6 studies |
Liquid based cytology sub-types | |||||
Precipitation-LBC (SurePath) | 85.2 % (74.4–91.9) I 2 = 76; 3 studies | 83.6 % (70.7–91.5) I 2 = 85; 3 studies | 99.5 % (97.6–99.9) I 2 = 0; 3 studies | 99.5 % (97.6–99.9) I 2 = 0; 3 studies | 35.4 % (14.5–63.9) I 2 = 91; 3 studies |
Filtration-LBC (ThinPrep) | 77.3 % (67.1–85) I 2 = 49; 5 studies | 68.3 % (55.3–79) I 2 = 64; 5 studies | 99.5 % (97.6–99.9) I 2 = 0; 4 studies | 99.5 % (97.6–99.9) I 2 = 0; 3 studies | 50.9 % (24.4–76.9) I 2 = 92 3 studies |
CS, conventional smear; LBC, liquid-based cytology; PPV, positive predictive value; NPV, negative predictive value.