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. 2020 May 20;477(5):717–724. doi: 10.1007/s00428-020-02835-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Staining patterns of fibroblasts for CD34 and αSMA in two selected cases of invasive lobular carcinoma (ILC) of the breast (a and c CD34 immunohistochemistry. b and d αSMA immunohistochemistry). a–b A case of ILC with homogenous distribution of CD34+ fibroblasts in the tumor stroma (a) and moderate density of αSMA+ myofibroblasts in the tumor stroma (b). c–d A case of ILC with loss of CD34+ fibroblasts in the tumor stroma (internal positive control of CD34+ endothelium, (c)) and homogenous distribution of strongly αSMA+ myofibroblasts in the tumor stroma (d)