Table 2.

Antibacterial effect of 5 biofilm inhibitors in combination with anti-A. baumannii antibiotics on extensively drug-resistant A. baumannii.

Biofilm inhibitor	Antibiotic	Fractional Inhibitory Concentration Index (FICI)									Interplay
		AB1	AB2	AB3	AB4	AB5	AB6	AB7	AB8	AB9	Synergy (%)	Additivity (%)	Indifference (%)	Antagonism (%)
Zinc lactate +	Imipenem	0.75	0.75	0.75	0.75	0.75	0.38	0.62	0.50	0.50	33	67	0	0
	Meropenem	0.75	1.00	0.75	0.75	0.56	0.75	0.50	0.50	0.38	33	67	0	0
	Tigecycline	0.31	1.06	0.56	0.31	1.06	0.56	0.56	0.56	0.56	22	56	22	0
	Polymyxin B	2.06	4.12	4.12	3.00	4.12	2.06	2.06	2.06	2.06	0	0	0	100
Fluoride +	Imipenem	0.56	0.31	0.56	1.00	1.00	0.56	0.31	0.56	0.31	33	67	0	0
	Meropenem	0.56	0.56	0.56	0.63	0.5	0.56	0.31	0.31	0.31	44	56	0	0
	Tigecycline	0.19	0.56	0.31	0.31	0.56	0.56	0.31	0.56	0.31	56	44	0	0
	Polymyxin B	1.06	1.12	1.12	1.12	1.12	1.25	1.12	1.25	1.12	0	0	100	0
Furanone +	Imipenem	0.56	0.56	0.56	0.56	0.75	0.63	0.63	0.56	0.56	0	100	0	0
	Meropenem	0.56	0.56	0.63	0.56	0.56	0.56	0.56	0.56	0.56	0	100	0	0
	Tigecycline	0.31	1.06	0.56	0.56	1.12	1.06	0.56	1.06	0.56	11	44	44	0
	Polymyxin B	1.25	1.25	2.5	1.25	1.12	4.00	1.25	1.25	1.25	0	0	78	22
Rifampicin +	Imipenem	1.00	1.06	0.53	0.63	0.53	1.06	0.56	0.56	0.56	0	78	22	0
	Meropenem	0.53	0.53	0.53	1.03	1.03	1.06	1.06	0.56	0.53	0	56	44	0
	Tigecycline	0.5	1.00	0.56	0.56	0.56	0.56	1.12	0.50	0.56	22	67	11	0
	Polymyxin B	0.56	0.53	0.53	0.56	0.56	1.03	0.56	0.63	0.56	0	100	0	0
Azithromycin +	Imipenem	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	0	0	100	0
	Meropenem	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	0	0	100	0
	Tigecycline	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	1.03	0	0	100	0
	Polymyxin B	0.62	0.62	0.73	0.73	0.73	0.73	0.73	0.73	0.73	0	100	0	0