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. 2020 Oct 22;10:17986. doi: 10.1038/s41598-020-75105-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Graphs of R₁ and R₁-difference in tumour and peritumoral area. The R₁ and R₁-difference histograms of all voxels for all patients within respective ROI. (A) the values for R₁ preGD (dashed line) and postGD injection (dotted line) are depicted for the NAWM, tumour and peritumoral ROIs. The lines shift to the right after contrast agent injection. (B) shows the R₁-difference (contrast enhancement) histogram for the peritumoral (blue) and the NAWM (black) ROIs for all patients. The R1-difference is significantly higher in the peritumoral area compared to NAWM (p = 0.048).