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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: Nature. 2020 Aug 5;586(7830):567–571. doi: 10.1038/s41586-020-2622-0

Extended Data Figure 7. mRNA-1273 and SAS-adjuvanted S-2P protein elicit both IgG2a and IgG1 subclass S-binding antibodies.

Extended Data Figure 7.

BALB/cJ (a-c) or C57BL/6J (d-f) mice (n=10/group) were immunized at weeks 0 and 3 with 0.01 (green), 0.1 (blue), or 1 μg (red) of mRNA-1273 or SARS-CoV-2 S-2P protein adjuvanted with SAS. Sera were collected 2 weeks post-boost and assessed by ELISA for SARS-CoV-2 S-specific IgG1 and IgG2a or IgG2c for BALB/cJ and C57BL/6J mice, respectively. Endpoint titers (a-b, d-e) and endpoint titer ratios of IgG2a to IgG1 (c) and IgG2c to IgG1 (f) were calculated. For mice for which endpoint titers did not reach the lower limit of detection (dotted line), ratios were not calculated (N/A). Data are presented as GMT +/− geometric SD (a-b, d-e) or mean +/− SD (c,f).