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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Nature. 2020 Oct 7;586(7830):600–605. doi: 10.1038/s41586-020-2785-8

Figure 3 |. Distinct trajectories of melanoma evolution.

Figure 3 |

Based on the data shown here and in conjunction with previous genetic, clinical, and histopathologic observations, we propose that melanomas can evolve via distinct trajectories, depending upon the order in which mutations occur. MAPK = Mitogen-Activated Protein-Kinase.