Table 3. Linear Regression Model for Differentially Expressed HDL Proteins and Stroke Recovery Swcores.
A model adjusting for NIHSS baseline scores was used to determine whether HDL protein changes from 24 to 96 h poststroke intervention are related to stroke recovery, as assessed at 3 mo poststroke by NIHSS. Benjamini-Hochberg correction was performed to correct for multiple testing (38 tests). Nine proteins corelated significantly with stroke recovery.
| Protein | Adj. R2 | Intercept | (SE) | F statistic | (DF) | P value | Adj. P value |
|---|---|---|---|---|---|---|---|
| APOF | 0.734 | −6.51 | (3.32) | 24.41 | (15) | 1.92E-05 | 7.30E-04 |
| APOL1 | 0.599 | 0.78 | (4.08) | 13.72 | (15) | 4.10E-04 | 0.008 |
| APMAP | 0.413 | 1.80 | (5.13) | 6.99 | (15) | 0.007 | 0.041 |
| LPA | 0.599 | −8.40 | (5.22) | 9.96 | (10) | 0.004 | 0.041 |
| APOC4 | 0.411 | 6.15 | (5.93) | 6.93 | (15) | 0.007 | 0.041 |
| APOM | 0.399 | −1.38 | (4.91) | 6.64 | (15) | 0.009 | 0.041 |
| PCYOX1 | 0.452 | 1.26 | (4.86) | 8.01 | (15) | 0.004 | 0.041 |
| PON1 | 0.401 | −1.76 | (4.89) | 6.68 | (15) | 0.008 | 0.041 |
| APOE | 0.380 | 1.22 | (5.23) | 6.21 | (15) | 0.011 | 0.046 |
Model: NIHSS-3 months ≈NIHSS baseline + protein Log2FC. APMAP indicates adipocyte plasma membrane-associated protein; APOE, apolipoprotein E; APOF, apolipoprotein F; HDL, high-density lipoprotein; NIHSS, National Institutes of Health Stroke Scale; and PON1, serum paraoxonase/ arylesterase.