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. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Nat Microbiol. 2020 Jul 27;5(11):1319–1329. doi: 10.1038/s41564-020-0763-4

Extended Data Fig. 3. Sulfamethoxazole (SMX) drug stress responses of colipterins 1–8 in the pathogenic E. coli LF82 and commensalistic E. coli BW25113.

Extended Data Fig. 3

Yellow area for optical density (OD600) measurement represents a range of sub-lethal concentrations of SMX against both E. coli LF82 (a) and BW25113 (b) strains. Peaks were extracted using EIC method corresponding to the m/z of colipterins 1-8 within a 10 ppm window. Red and black lines indicate Ctrl (Control, no SMX treatment) and SMX, respectively, in the MS chromatogram. Intensities in the bar graphs indicate integration value of EIC peak area. The mean and s.d. (error bars) from three biological experiments (n = 3) are shown. P values were analyzed by a two-tailed unpaired t-test; ns, not significant.