Table 4.

Metabolic status, echocardiographic, 24 h Holter-ECG and 24 h-blood pressure monitoring findings in patients with adrenal insufficiency on conventional treatment and 6 months after switching to once daily modified release hydrocortisone (OD-HC)

	Conventional treatment (n = 10)	OD-HC treatment (n = 10)	Controls (n = 10)	P*	P#
Metabolic status
Glycaemia (mg/dL)	81 (67–159)	83 (72–106)	83 (63–102)	0.244	0.953
Total cholesterol (mg/dL)	233 (152–321)	205 (152–241)	192 (162–230)	0.028	0.678
LDL-cholesterol (mg/dL)	135 (70–223)	109 (65–158)	125 (98–175)	0.028	0.139
Triglycerides (mg/dL)	111 (59–214)	92 (43–187)	146 (112–198)	0.176	0.066
Echocardiography
IVSTDd (mm)	9.0 (7.7–11.7)	9.0 (5.0–11.5)	9.0 (8.0–10.0)	0.461	0.496
LVEDd (mm)	45.8 (42.1–56.0)	44.4 (40.0–52.0)	49.5 (48.0–55.0)	0.123	0.008
LAD (mm)	35.0 (30–44.0)	35.0 (28.0–37.0)	35.5 (33.0–41.0)	0.194	0.176
LVEF (%)	60.0 (50.0–68.3)	62.4 (50.6–70.0)	56.0 (50.0–64.0)	0.674	0.327
24 h-blood pressure
MAP-S day (mmHg)	123 (96–138)	118 (101–138)	126 (108–135)	0.342	0.141
MAP-D day (mmHg)	76 (65–89)	75 (64–90)	76 (63–86)	0.374	0.398
MAP-S night (mmHg)	106 (94–138)	115 (90–131)	122 (103–127)	0.678	0.086
MAP-D night (mmHg)	63 (54–86)	72 (59–101)	71 (60–82)	0.028	0.674
Holter-ECG
HR day (bpm)	81 (73–86)	81 (72–96)	81 (66–89)	0.400	0.646
HR night (bpm)	75 (58–90)	72 (55–86)	71 (48–79)	0.833	0.362

Data are presented in median (range). No cases of supraventricular tachycardia and ventricular tachycardia were recorded

bpm beats per minute, HR heart rate, bpm beats per minute, IVSTDd interventricular septum thickness at diastole, LAD left atrial diameter, LVEDd left ventricular end-diastolic diameter, LVEF left ventricular ejection fraction, MAP-D mean arterial pressure-diastolic, MAP-S mean arterial pressure-systolic

P* Conventional treatment vs. OD-HC treatment; P# OD-HC treatment vs. Controls