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. 2020 Jun 9;196(11):1018–1033. doi: 10.1007/s00066-020-01637-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Radiotherapy-related changes in serum metabolome of the prostate adenocarcinoma patients treated with IMRT and SABR. a Numbers of compounds in different classes of metabolites that changed their abundances between pre-RT sample A and either post-RT sample B, C, or D (uncorrected p < 0.05). Samples from patients subjected to IMRT and SABR are compared in the following classes: phosphatidylcholines (PC; 67 compounds in total), lysophosphatidylcholines (LPC; 9), sphingomyelins (SM; 13), acylcarnitines (acylc.; 11), amino acids (AA; 21), biogenic amines (amines; 16). b Changes in the ratio of total LPC versus PC (LPC/PC) quantitated in sera of individual patients from both groups. Hash indicates comparisons showing at least a very large effect size (|d| ≥ 1.2)