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. 2020 Apr 23;34(12):3310–3322. doi: 10.1038/s41375-020-0828-7

Fig. 2. MV-NIS virotherapy induces increased T-cell reactivity against MAGE-C1 and MAGE-A3.

Fig. 2

a Of the ten tumor-associated antigens, T-cell responses against MAGE-C1 and MAGE-A3 were significantly increased in patient peripheral blood mononuclear cell samples after measles virus-sodium iodide symporter (MV-NIS) virotherapy. (n = 10). Gray-shaded area denotes the limit of negative response. b Representative image showing increased IFN-γ responses against MAGE-C1, MAGE-A1, and MUC-1 at 6 weeks after MV-NIS virotherapy. CEF peptide pool was used as a positive control. Sole asterisk indicates P < 0.05, double asterisks, P < 0.01; triple asterisks, P < 0.001, compared with the corresponding groups. Error bars indicate mean with standard error of mean. CEF indicates CEF-positive control peptide pools; CT/DMSO control/dimethylsulfoxide, IFN interferon.