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. 2020 Oct 9;10:588530. doi: 10.3389/fonc.2020.588530

FIGURE 1.

FIGURE 1

Overexpression of serine hydroxymethyltransferase (SHMT2) in primary oral squamous cell carcinoma (OSCC). (A) Representative immunohistochemical staining of SHMT2 in oral mucosa (left) and primary OSCC (right). The scale bar represents 50 μm. (B) Histoscores of SHMT2 as SHMT2 expression levels in OSCC (n = 176), dysplasia tissue (DYS, n = 69), and normal oral mucosa (MUC, n = 42). (C) The expression of SHMT2 in OSCC sample and oral mucosa sample of each OSCC patient (n = 3) was shown by Western blotting, and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was defined as a loading control. (D,E) Kaplan–Meier survival analysis of low and high expression of SHMT2 in OSCC based on microarrays]the median value was used for (D), log-rank analysis; the best cutoff value was used for (E), log-rank analysis]. (F,G) Kaplan–Meier survival analysis of low and high expression of SHMT2 in OSCC based on The Cancer Genome Atlas (TCGA) database [the median value was used for (F), log-rank analysis; the best cutoff value was used for (G), log-rank analysis]. Data are represented as the mean ± SEM and analyzed by one-way ANOVA with post hoc Tukey test or log-rank analysis. *P < 0.05; **P < 0.01; ***P < 0.001.