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. 2020 Oct 9;10:588530. doi: 10.3389/fonc.2020.588530

FIGURE 2.

FIGURE 2

Increased expression of serine hydroxymethyltransferase (SHMT2) of oral squamous cell carcinoma (OSCC) patients with advanced pathological grade. (A) Representative hematoxylin–eosin (HE, Top) and immunohistochemical staining (bottom) of SHMT2 in Grade I tissue, Grade II tissue, and Grade III tissue. The scale bar represents 50 μm. (B) Histoscores of SHMT2 based on microarrays among Grade I tissues (n = 52), Grade II tissues (n = 101), and Grade III tissues (n = 23). (C) Expression of SHMT2 in OSCC based on The Cancer Genome Atlas (TCGA) database among Grade I tissues (n = 48), Grade II tissues (n = 192), and Grade III tissues (n = 63). (D) Correlations between module eigengenes (the SHMT2 gene in the blue module) and clinical traits. Each unit of the table consists of the corresponding correlation coefficient and P-value. The color scale represents the strength of the correlation. Data are represented as the mean ± SEM and analyzed by one-way ANOVA with post hoc Tukey’s test. ns, no significance; **P < 0.01; ***P < 0.001.