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. 2020 Oct 9;10:588530. doi: 10.3389/fonc.2020.588530

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Copyright © 2020 Wu, Wang, Yang, Wang, Yang, Liu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Weighted gene co-expression network analysis (WGCNA) of serine hydroxymethyltransferase (SHMT2)-related genes. (A) Analysis of scale-free topology for various soft-thresholding power. We selected β = 4 as the soft thresholding power. (B) Dendrogram of genes was clustered based on a dissimilarity measure (1-TOM). The genes were divided into several modules. Module Blue contained the SHMT2 gene. (C) Scatter plot of gene significance for grade vs. module membership in the blue module (correlation coefficient = 0.29, P < 0.001).