TABLE 1.

Multivariate analysis for overall survival in primary OSCC patient cohort of microarrays (best cutoff value was used as a cutoff value).

Parameters	HR (95% CI)	P-value
Gender	0.996 (0.380∼2.609)	0.993
Age	1.640 (0.783∼3.435)	0.190
Smoking	0.999 (0.416∼2.398)	0.998
Drinking	0.587 (0.243∼1.422)	0.238
Pathological grade
I + II vs. III	1.275 (0.514∼3.164)	0.600
Node stage
N1 vs. N0	0.914 (0.368∼2.272)	0.846
N2 vs. N0	2.490 (0.952∼6.513)	0.063
Tumor size
T2 vs. T1	1.202 (0.393∼3.676)	0.747
T3 vs. T1	1.675 (0.496∼5.650)	0.406
T4 vs. T1	2.101 (0.473∼9.329)	0.329
SHMT2 expression	2.474 (1.214∼5.044)	0.013*

Cox proportional hazards regression model; HR, hazard ratio; 95% CI, 95% confidence interval; *P < 0.05. OCSS, oral squamous cell carcinoma; SHMT2, serine hydroxymethyltransferase.