TABLE 3.

Multivariate analysis for overall survival in primary OSCC patient cohort of TCGA database (best cutoff value was used as a cutoff value).

Parameters	HR (95% CI)	P-value
Gender	0.958 (0.622∼1.478)	0.848
Age	1.193 (0.751∼1.895)	0.455
Race	1.099 (0.739∼1.635)	0.642
Pathological grade
II vs. I	1.309 (0.699∼2.450)	0.400
III vs. I	1.611 (0.831∼3.123)	0.158
Node stage
N1 vs. N0	1.016 (0.559∼1.849)	0.958
N2 vs. N0	1.484 (0.739∼2.980)	0.267
N3 vs. N0	0.000 (0.000)	0.983
Tumor size
T2 vs. T1	2.538 (0.289∼22.254)	0.401
T3 vs. T1	5.024 (0.636∼39.678)	0.126
T4 vs. T1	3.169 (0.404∼24.829)	0.272
Stage
Stage 2 vs. Stage 1	0.796 (0.066∼9.604)	0.858
Stage 3 vs. Stage 1	0.515 (0.047∼5.656)	0.587
Stage 4 vs. Stage 1	0.558 (0.050∼6.212)	0.635
SHMT2 expression	2.306 (1.502∼3.542)	0.000*

Cox proportional hazards regression model; HR, hazard ratio; 95% CI, 95% confidence interval; *P < 0.05. OSCC, oral squamous cell carcinoma; SHMT2, serine hydroxymethyltransferase; TCGA, The Cancer Genome Atlas.