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. 2020 Oct 9;10:574861. doi: 10.3389/fonc.2020.574861

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Copyright © 2020 Gao, Gupta, Cui, Ashar, Wu, Zeng, Lei, Teng, Ashby, Guan and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of sapitinib on the ATPase activity of ABCB1 transporter and the growth of multicellular tumor spheroids. (A) Effect of sapitinib (0.625–40 μM) on the ATPase activity of ABCB1 transporter in membrane vesicles of High Five insect cells. (B) The effect of the incubation of sapitinib, paclitaxel and the paclitaxel + sapitinib on the growth of SW620/Ad300 MCTSs (sapitinib: 5 μM; paclitaxel: 1 μM). Scale bar = 300 μm. (C) The corresponding relative volume change (V/V0) from control ***P < 0.001 versus Paclitaxel.