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. 2020 Oct 22;10:18099. doi: 10.1038/s41598-020-75197-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vitamin B₆, B₁₂ and folate cofactor dependent proteins network and pathway annotation analysis. (A) KEGG pathways showing one carbon pool by folate, Cysteine and Methionine metabolism, Taurine and Hypotaurine metabolism. (B) Reactome pathways showing degradation of cysteine and homocysteine pathway. (C) WikiPathways showing Vitamin B₁₂, folate, Transulfuration and one carbon metabolism pathway. (D) Overlay of gene expression values onto cofactor—protein pathways showing upregulated genes (Red—upregulated).