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. 2020 Oct 22;10:18099. doi: 10.1038/s41598-020-75197-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Integration of AVNFH omic analyses: (A) Integrated network of AVNFH transcriptomics, Proteomics, SNP genes and cofactor—protein network. Red nodes are hub genes, among which CBS and MUT showed highest network centrality scores. (B) WikiPathways annotation analysis of hub genes showing Vitamin B₁₂, folate metabolism, transulfuration and one carbon metabolism. (C) Reactome pathways showing Iron uptake, transferrin endocytosis, scavenging heme from plasma, megaloblastic anemia pathways. (D) KEGG pathways showing HIF signaling, cysteine and methionine metabolism, one carbon pool by folate pathways. (E) Gene expression values of genes belonging to different modules like elevated homocysteine, hypoxia, osteoclastogenesis, endochondral ossification as well as coagulation and vasoconstriction from transcriptomics analysis.