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. 2020 Oct 22;10:18120. doi: 10.1038/s41598-020-74648-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the distribution of key properties between resistant and susceptible Mtb mutations. Selected properties included structure-based features (change in nucleic acid affinity, deformation energy and distance to nucleic acid) and sequence-based features (PROVEAN, SIFT and rate of evolution scores). Statistical significance calculated by Welch sample t-test.