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. 2020 Oct 22;11(10):894. doi: 10.1038/s41419-020-03029-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a MNX1 protein was markedly increased in pcDNA-MNX1-AS1 or pcDNA-MNX1 transfected RBE cells and significantly decreased in si-MNX1-AS1 or si-MNX1 transfected FRH0201 cells. The experiment was repeated three times for each group (***P < 0.001 by t-test). b The GeneCards and PROMO databases were used to predict TFs which may bind to the promoter region of MNX1. Only five TFs were shared between the two databases: YY1, c-Myc, MAZ, USF1, WT1. c ChIP assay showed the enrichment of c-Myc and MAZ over the MNX1 promoter region in FRH0201 and RBE cells. d The expression level of MNX1 protein was significantly decreased in si-c-Myc or si-MAZ transfected FRH0201 cells. e RegRNA database was used to predict c-Myc and MAZ binding sites on the nucleotide sequence of MNX1-AS1, which indicated that the binding sites did exist. RIP assay in FRH0201 cells further determined the previous predicting results. The experiment was repeated three times for each group. (***P < 0.001 by t-test).