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. 2020 Oct 22;11(10):894. doi: 10.1038/s41419-020-03029-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The effect of MNX1-AS1 on tumor formation after subcutaneous transplantation in vivo. The left image showed the dissected tumors from FRH0201 cells stably transfected with scrambled (NC-MNX1-AS1 group) or sh-MNX1-AS1 (SH-MNX1-AS1 group); the middle image showed the tumor volume growth curves of SH-MNX1-AS1 and NC-MNX1-AS1 groups between 0 and 4 weeks; the right image showed the scatter plots of tumor weight with horizontal lines. The results clarified that downregulated MNX1-AS1 repressed the growth of ICC in vivo. (***P < 0.001 by t-test). b The effect of MNX1-AS1 on tumor metastasis in vivo. The left image showed the dissected lungs from FRH0201 cells stably transfected with scrambled (NC-MNX1-AS1 group) or sh-MNX1-AS1 (SH-MNX1-AS1 group); the middle image showed Hematoxylin–Eosin (HE) staining and Ki-67 IHC staining between the two groups; the right image showed Ki-67 IHC score between the two groups. (**P < 0.01 by t-test). The IHC staining was repeated three times for each group. The results indicated that downregulated MNX1-AS1 repressed the metastasis of ICC in vivo.