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. 2020 Oct 22;11(10):894. doi: 10.1038/s41419-020-03029-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — LncRNA MNX1-AS1 facilitates the expression of MNX1 via recruiting transcription factors c-Myc and MAZ in the nucleus. Then, the MNX1 protein prompts the expression of Ajuba protein via binding to its promoter region. The increasing Ajuba protein in the cytoplasm subsequently suppresses the Hippo pathway by inhibits Mst1/2 and Lats1. These processes eventually lead to the increasing of YAP1 in the nucleus. The elevated YPA1 in the nucleus facilitates the tumorigenesis of ICC.