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. 2020 Oct 9;11:566893. doi: 10.3389/fimmu.2020.566893

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Copyright © 2020 Paris, Chapat, Pasin, Lambiel, Sharrock, Shukla, Sigoillot-Claude, Bonnet, Poulet, Freyburger and De Luca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pro-inflammatory and anti-microbial responses of canine macrophages after a full immune training. (A) IL12p40 secretion (Means ± SD). (B) IL-10 secretion (Means ± SD). (C) IFN-γ secretion (Means ± SD). (D) Principal component analysis of IL-6, IL-10, TNF-α and IFN-γ, secretion after a full immune training. (E) ROS production (geometric mean of fluorescence intensity ± SD). (F) Phagocytic activity (Total intensity of fluorescence of E. coli beads integrated per number of red-fluorescing cells). ANOVA tests p-values * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001.