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. 2020 Oct 9;11:566893. doi: 10.3389/fimmu.2020.566893

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Copyright © 2020 Paris, Chapat, Pasin, Lambiel, Sharrock, Shukla, Sigoillot-Claude, Bonnet, Poulet, Freyburger and De Luca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic and metabolic features regulate trained immunity implementation in canine macrophages. (A–C) Inhibition of histone methylation by MTA abrogates the enhanced cytokine production (Means ± SD). (D–F) Inhibition of glycolysis by 2-DG abrogates the enhanced cytokine production (Means ± SD). (G–I) Glycolytic flux is increased by full immune training (Means of scaled intensity ± SD). ANOVA tests p-values * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001.