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. 2020 Oct 22;10:18058. doi: 10.1038/s41598-020-74848-6

Figure 1.

Figure 1

Chronic bryostatin-1 improves the behavioral phenotypes in hyperactivity of the Fmr1 KO2 mice in an open field test. Wild-type (WT) or Fmr1 KO2 (KO) adult mice were treated with vehicle (V) or bryostatin 1 (Bryo) for 5 weeks (Study 1) or 13 weeks (Study 2) and then tested in open field. From T1 to T3, data are shown for hyperarousal (Number of Squares crossed in the open field test) (first time tested in the open field or T1), 10 min after the first open field test (second time exposed to the open field or T2), and 24 h after the first open field test (third time exposed to the open field or T3). We identified a significant improvement in Study 2, T 2 in the open field when compared to WT littermates (P = 0.4031). Data is visualized as boxplots with interquartile ranges, presenting all the data points. The table indicates the mean standard deviation and the standard error of the mean (N = 10 mice per group).