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. 2020 Oct 22;10:18058. doi: 10.1038/s41598-020-74848-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chronic bryostatin-1 rescues impaired learning and memory of the Fmr1 KO2 mice in contextual fear conditioning. Wild-type (WT) or Fmr1 KO2 (KO) adult mice were treated with vehicle (V) or bryostatin-1 (Bryo) for 5 weeks (Study 1) or 13 weeks (Study 2) and then tested in contextual fear conditioning. Significant improvement in cognitive behavior is observe in Fmr1 KO2 mice following chronic treatment with Bryostatin 1 for 13 week when compared to wild type littermates (P = 0.7078). Data is visualized as boxplots with interquartile ranges, presenting all the data points. The table indicates the mean standard deviation and the standard error of the mean (N = 10 mice per group).