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. 2020 Oct 22;11(10):892. doi: 10.1038/s41419-020-03106-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Relative mRNA and protein expression level of TIM in seven breast cancer cell lines and normal mammary epithelial cell line HBL100. Values are means ± SD. c, d The interference efficiency of TIM via small interfering (siRNA) in MCF7 and T47D cells. Values are means ± SD, ***p < 0.001 (Student’s t-test). e, f Cell viability of MCF7 and T47D cells interfered by siRNA. Values are means ± SD, ***p < 0.001 (Student’s t-test). g Colony formation assay of MCF7 and T47D stably interfered by shRNA. Values are means ± SD, ***p < 0.001 (Student’s t-test). Scale bar is 5 mm. h Orthotopic xenograft transplanted with shNC and shTIM/MCF7 cells (n = 5). Scale bar is 10 mm. i Tumor volume at day 30 was measured in each group. Values are means ± SD, **p < 0.01 (Student’s t-test). j Tumor weight at day 30 was measured in each group. Values are means ± SD, *p < 0.05. k Representative images of Ki67 staining in orthotopic xenograft tissue from shNC and shTIM mice. Scale bar is 50 mm.