Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 22;10:18110. doi: 10.1038/s41598-020-75153-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

NaR9 effectively protects mice from airway hyperresponsiveness (AHR) and Th2-mediated lung inflammation. (a) Protocol used for NaR9 treatment. (b) AHR of the mice indicated was measured by administering methacholine (Mch). (c, d) In bronchoalveolar lavage fluid (BALF), total numbers of cells and numbers of eosinophils were counted. (e) Proportions of eosinophils and neutrophils in BALF were measured by flow cytometry using the markers indicated. (f) Representative images of hematoxylin and eosin stained histologic sections of mouse lungs. Scale bars, 200 μm. The inflammatory score (0 to 3) was statistically analyzed. (g) Lung Il13, Il5, and Hprt mRNA levels were measured in the mice indicated. (h) Mediastinal lymph node cells from house dust mite (HDM)-sensitized mice were restimulated with HDM (10 or 30 μg/mL). Five days later, IL-5, IL-13, and IL-17a were measured in the culture supernatants by ELISA. Data are presented as means ± SD of three independent experiments (n = 4 or 5 each). n.s. not significant, WT wild type, i.t. intratracheally, Rrs respiratory resistance.