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. 2020 Oct 9;8:587685. doi: 10.3389/fcell.2020.587685

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Copyright © 2020 Gupta, Ambaru and Bajaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Asymmetry observed in the LdCor coiled coil domain tetramer. Cartoon represents the pairs of dimers, highlighting the asymmetry. In left panel, Cα atoms of aa residues 475–507 of chain C were superposed to corresponding atoms of chain A using Superpose (Krissinel and Henrick, 2004) and the transformation applied to the BC dimer. The B and D helices of AD/BC dimers superpose with an RMSD of 3.4 Å. (B) Interactions at the BC dimer are different from that of AD dimer due to an upward shift in B helix by a heptad. Also, the distances across the interface are longer in the BC helical interface (Taken from Nayak et al., 2016 with permission).