TABLE 1.
Presence of actin and actin-like proteins in five main disease causing trypanosomatids.
| Trypanosoma cruzi | Trypanosoma brucei | Leishmania donovani | Leishmania major | Leishmania braziliensis | |
| Chagas disease | Sleeping sickness | Visceral Leishmaniasis | Cutaneous Leishmaniasis | Mucocutaneous Leishmaniasis | |
| Actin | TcAct1* (TcCLB.510571.30) (TcCLB.510127.79) | ActinA* (Tb927.9.8850) ActinB (Tb927.9.8880) | LdAct (LDBPK_041250) | LmjF.04.1230 | LbrM.04.1250 |
| Actin 2 | TcAct2 (TcCLB.507129.10) | Absent | Absent | Absent | Absent |
| Actin, putative (actin 3rd) | TcCLB.510945.30 | Absent | Absent | Absent | Absent |
| Actin, putative (actin 4th) | TcCLB.503841.40 | Absent | LdBPK_350810.1 (actin-like protein) | LmjF.35.0790 (actin-like protein) | LbrM.34.0780 (actin-like protein) |
| Actin -like protein 1 | TcCLB.508277.330 | Tb927.9.5440 | LdBPK_151350.1 | LmjF.15.1330 | LbrM.15.1280 |
| Actin -like protein 2 | TcCLB.506405.30 | Tb927.4.980 | LdBPK_343560.1 | LmjF.34.3760 | LbrM.20.3360 |
| Actin -like protein 3 | TcCLB.506733.50 | Tb927.11.3880 | LdBPK_130840.1 | LmjF.13.0950# | LbrM.13.0760 |
| Actin -like protein 4 | TcCLB.510719.110 | Tb927.11.10110 | LdBPK_363470.1 | LmjF.36.3310 | LbrM.35.3540 |
| Actin -like protein 5 | TcCLB.506695.10 | Tb927.3.3020 | LdBPK_292850.1 | LmjF.29.2740 | LbrM.29.2800 |
| Member of ARP6 family (Actin like protein) | TcCLB.508951.29 | Tb927.10.2000 | LdBPK_210290.1 | LmjF.21.0230 | LbrM.21.0300 |
The data was downloaded from the TriTrypDB version 48 database (www.tritrypdb.org). IDs of strains used: T. cruzi CL Brener Esmeraldo-like; T. brucei brucei TREU927; L. donovani BPK282A1; L. major strain Friedlin; L. braziliensis MHOM/BR/75/M2904. *This actin locus contains two copies of the gene on one allele and one copy on the second allele (Ben Amar et al., 1988; Cevallos et al., 2003). #This has been referred as actin-like protein 3 in Cevallos et al. (2011) and as ARP1 in Singh et al. (2014).