TABLE 2.
Presence of actin binding proteins in five main diseases causing trypanosomatids, compared to higher eukaryotes.
| Higher eukaryotes | Trypanosoma cruzi | Trypanosoma brucei | Leishmania donovani | Leishmania major | Leishmania braziliensis | |
| Disease caused | NA | Chagas disease | Sleeping sickness | Visceral Leishmaniasis | Cutaneous Leishmaniasis | Mucocutaneous Leishmaniasis |
| Actin monomer binding | Profilin | TcCLB.510911.10 | Tb927.11.13780 | LdBPK_320550.1 | LmjF32.0520 | LbrM.32.0570 |
| Thymosin B4 | Absent | Absent | Absent | Absent | Absent | |
| ADF/Cofilin | TcCLB.510145.20 | Tb927.3.5180 | LdBPK_290520.1 | LmjF29.0510 | LbrM.29.0450 | |
| Gelsolin | Absent | Absent | Absent | Absent | Absent | |
| Twinfilin | TcCLB.506559.300 | Tb927.4.2350 | LdBPK_342060.1 | LmjF.34.2290 | LbrM.20.1790 | |
| CAP/Srv2 | TcCLB.504137.80 | Tb927.10.9250 | LdBPK_365830.1 | LmjF36.5590 | LbrM.35.5860 | |
| Filament binding | Myosin | TcCLB.511527.70 (myosin 13) TcCLB.507739.110 (1B heavy chain) TcCLB.504867.120 MyoA TcCLB.506779.190 MyoB TcCLB.504103.30 MyoC TcCLB.503905.10 MyoD TcCLB.503905.10 MyoE TcCLB.507445.50 MyoF TcCLB.507093.210 MyoG | Tb927.11.16310 (Unconventional myosin) Tb927.4.3380 (1B heavy chain) Tb927.9.1340 (myosin like protein 2) Tb927.11.330 (myosin like protein 1) | LdBPK_324020.1 (myosin XXI) LdBPK_341070.1 (1B heavy chain) | LmjF.32.3870 (myosin XXI) LmjF.34.1000 (1B heavy chain) | LbrM.32.4110 (myosin XXI) LbrM.20.0970 (1B heavy chain) |
| Coronin | TcCLB.510515.100 | Tb927.8.3100 | LdBPK_231400.1 | LmjF.23.1165 | LbrM.23.1260 | |
| CAPz | TcCLB.506181.90 TcCLB.506363.60 | Absent | Absent | Absent | Absent | |
| Nucleating | Arp2/3 complex (7 subunits) Arp2 | TcCLB.511361.40 | Tb927.10.15800 | LdBPK_191190.1 | LmjF19.1200 | LbrM.19.1370 |
| Arp3 | TcCLB.508277.260 | Tb927.9.5350 | LdBPK_151410.1 | LmjF.15.1360 | LbrM.15.1360 | |
| ARPC1 | TcCLB.504215.40 | Tb927.10.13190 | LdBPK_180920.1 | LmjF.18.0920 | LbrM.18.0980 | |
| ARPC2 | TcCLB.506865.10 | Tb927.8.4410 | Absent | Absent | Absent | |
| ARPC3 | TcCLB.510963.70 | Tb927.10.4540 | Absent | Absent | Absent | |
| ARPC4 | TcCLB.509127.104 | Tb927.2.2900 | LdBPK_020570.1 | LmjF.02.0600 | LbrM.02.0580 | |
| ARPC5 | TcCLB.442297.10 | Tb927.10.10600 | LdBPK_050290.1 | LmjF.05.0285 | LbrM.05.0280 | |
| ARPC-like | Absent | Absent | LdBPK_101080.1 | LmjF.10.1000 | LbrM.10.1100 | |
| Formin | TcCLB.511313.30 TcCLB.506203.80 TcCLB.511393.30 | Tb927.5.2300 Tb927.11.5740 | LdBPK_171040.1 LdBPK_241130.1 | LmjF24.1110 LmjF17.0930 | LbrM.17.0950 LbrM.24.1120 | |
| Crosslinking proteins | Fimbrin, villin, α- actinin, plastin, spectrin, filamin | Absent | Absent | Absent | Absent | Absent |
The data was downloaded from the TriTrypDB version 48 database (www.tritrypdb.org). IDs of strains used: T. cruzi CL Brener Esmeraldo-like; T. brucei brucei TREU927; L. donovani BPK282A1; L. major strain Friedlin; L. braziliensis MHOM/BR/75/M2904.