Figure 4.

5-HT1B Neurons and 5-HT1B Receptors are Responsible for Restoring Aggression in Losers

(A and B) Optogenetic activation of 5-HT1B neurons promoted aggression (A) and decreased the latency to fight (B) in losers (n = 22–27).

(C and D) Inhibition of synaptic transmission of 5-HT1B neurons decreased the attack intensity (C) and increased the latency to fight (D) in socially isolated males (n = 23–25).

(E and F) Overexpressing 5-HT1B receptor in 5-HT1B neurons induced aggression (E) and decreased the latency to fight (F) in losers (n = 22–24). The Kruskal-Wallis test was performed for (A)-(B) and (E)-(F), and one-way ANOVA was performed for (C) and (D). ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.

See also Figure S7.