Suppressive Loser Mentality is Effectively Removed by Increasing Serotonin Signaling
(A) Optogenetic activation of Tph-Gal4 neurons in losers rendered a longer occupancy duration for food patches as an indication of territorial behavior (n = 28–34).
(B) Activating Tph-Gal4 neurons increased threat displays of losers (n = 19–24).
(C and D) The losers displayed lower courtship motivation than the winners (C). Elevating serotonin levels restored courtship motivation of losers (C) (n = 21–28) but did not affect the courtship motivation of singly raised males (D) (n = 20–22). One-way ANOVA was performed for (A)-(D). ns, not significant (P > 0.05); ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.