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. 2020 Oct 9;8:577215. doi: 10.3389/fcell.2020.577215

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Copyright © 2020 Peters, van Gemert, Kathmann, Reddy, Cillessen and Jansen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example combination index (CI)-fraction affected (FA) curve for HT cells exposed to PLX and BLS in a fixed molar ratio based on the IC50. Drug exposure was 72 h. The SEM was within the size of the markers. This plot was fit by the program based on the actual values, showing antagonism/additivity at high FA values. The plot also indicates which part of the curve (actual CI values above FA > 0.5; usually the CI value around the FA of 0.5, 0.75, and 0.9) was used to calculate the average CI value of each experiment.