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. 2020 Oct 9;8:582220. doi: 10.3389/fcell.2020.582220

FIGURE 1.

FIGURE 1

Downregulation of PTPRS correlated with poor prognosis in MPNST patients. (A) Representative immunostaining images of PTPRS weak/medium/strong and normal nerve tissue cases and proportions (%) of different levels of tissue microarray dots. (B) Relative PTPRS mRNA and protein levels in randomly selected cases of normal nerve tissues and MPNST tissues. β-actin was used as a loading control. **p < 0.05. (C) Kaplan–Meier’s curves for cumulative survival according to PTPRS level in MPNST cohort with available follow-up data (n = 29, p = 0.0184). PTPRS high referred as medium and strong stainings with a score 2 or 3. PTPRS low referred as negative and weak stainings with a score 0 or 1. (D) Correlation between expression of PTPRS positive cells in tissues of dead patients and survival time after surgery (p = 0.0003). PTPRS, protein tyrosine phosphatase receptor S; MPNST, malignant peripheral nerve sheath tumor; NNT, normal nerve tissue.