Table 1.

Clinical and pathological characteristics of studied tissue.

n = 105					Median age
					72 years
					High grade tumors
Gender	M	F
	74% (78)	26% (27)
pT-stage	T2a/b	T3a/b	T4a/b
	26% (27)	51% (54)	23% (24)
pN-stage	pN0	pN1–3	pNX
	69% (73)	23% (24)	8% (8)
Lymphovascular invasiona	LI+/VI−	LI−/VI−	VI+/LI−	LI+/VI+	N/A
	26% (27)	46% (49)	2% (2)	23% (24)	3% (3)
Tumor size	≥3 cm	<3 cm
	71% (75)	29% (30)
Histology	Urothelial	Squamous	Neuroendocrine	Mixed
	88% (93)	6% (6)	2% (2)	4% (4)

(n) number of subjects; (m) male; (f) female; (T2a/b) tumor invades (a) inner half or (b) outer half of muscularis propria bladder wall; (T3a/b) tumor invades perivesical tissue, (a) microscopically or (b) macroscopically; (T4a/b) tumor invades (a) prostate, uterus, vagina or (b) pelvic or abdominal wall; (pNX) regional lymph nodes cannot be evaluated histologically; (pN0) no regional lymph node metastasis; (pN1) metastases in a single lymph node, 2 cm or less in greatest dimension; (pN2) Metastases in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension, or multiple lymph nodes, none more than 5 cm in greatest dimension; (pN3) Metastasis in a lymph node more than 5 cm in greatest dimension; (LI+) tumor invades lymphatic vessel; (LI−) no lymphatic vessel invasion; (VI+) tumor invades blood vessel; (VI−) no blood vessel invasion; (N/A) data not available.

^aIn case of Lymphovascular invasion, LI and VI were considered as separated groups (LI+ = includes all patients with LI+/VI− and LI+/VI+; LI− = LI−/VI− and LI−/VI+; VI+ = VI+/LI− and VI+/LI+; VI− = VI−/LI− and VI−/LI+).