Table 3.
Uni- and stepwise multivariable Cox regression of glycosyltransferases.
| Survival | Variables | Univariable |
Multivariable |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| POFUT1 |
EXT1 |
B4GALT1 |
|||||||||
| HR | p-Value | HR | p-Value | HR | p-Value | HR | p-Value | ||||
| OS | GT | POFUT1− | POFUT1+ | 2.6512 | 0.0008 | 3.4104 | 0.0004 | ||||
| EXT1− | EXT1+ | 1.7791 | 0.0192 | 1.5835 | ns | ||||||
| B4GALT1− | B4GALT1+ | 1.7468 | 0.0566 | ns | |||||||
| Age | Continuous range | 2.7024 | 0.0910 | 3.9969 | 0.0173 | ||||||
| Gender | Female | Male | 1.2930 | 0.3506 | |||||||
| pT-stage | T3a/b | T2a/b | 2.6371 | 0.0023 | 2.3534 | 0.0152 | |||||
| T4a/b | T2a/b | 3.6504 | 0.0005 | ||||||||
| T4a/b | T3a/b | 1.3842 | 0.2562 | ||||||||
| pN-stage | pN+ | pN− | 2.2057 | 0.0073 | |||||||
| LI | LI+ | LI− | 2.9219 | <0.0001 | 2.5102 | 0.0009 | 2.7513 | <0.0001 | |||
| VI | VI+ | VI− | 2.2386 | 0.0037 | 1.9521 | 0.0425 | |||||
| TS | ≥3 cm | <3 cm | 1.4033 | 0.2063 | |||||||
| CSS | GT | POFUT1− | POFUT1+ | 4.4066 | 0.0003 | 4.9940 | 0.0001 | ||||
| EXT1− | EXT1+ | 2.2231 | 0.0137 | 2.0873 | 0.0235 | ||||||
| B4GALT1− | B4GALT1+ | 3.0541 | 0.0079 | 3.0721 | 0.0076 | ||||||
| Age | Continuous range | 0.6495 | 0.5516 | ||||||||
| Gender | Female | Male | 1.8607 | 0.0714 | |||||||
| pT-stage | T3a/b | T2a/b | 4.1017 | 0.0025 | 4.1072 | 0.0029 | |||||
| T4a/b | T2a/b | 6.0953 | 0.0007 | 4.2936 | 0.0079 | ||||||
| T4a/b | T3a/b | 1.4861 | 0.2766 | ||||||||
| pN-stage | pN+ | pN− | 2.5128 | 0.0122 | |||||||
| LI | LI+ | LI− | 4.5440 | <0.0001 | 4.4159 | <0.0001 | 4.5255 | <0.0001 | 4.4968 | <0.0001 | |
| VI | VI+ | VI− | 2.6483 | 0.0044 | |||||||
| TS | ≥3 cm | <3 cm | 1.1127 | 0.7508 | |||||||
| DFS | GT | POFUT1− | POFUT1+ | 2.9687 | 0.0058 | 2.4454 | 0.0455 | ||||
| EXT1− | EXT1+ | 1.9499 | 0.0343 | ns | |||||||
| B4GALT1− | B4GALT1+ | 2.2927 | 0.0397 | ns | |||||||
| Age | Continuous range | 0.8699 | 0.8399 | ||||||||
| Gender | Female | Male | 1.5387 | 0.2128 | |||||||
| pT-stage | T3a/b | T2a/b | 2.3974 | 0.0234 | |||||||
| T4a/b | T2a/b | 2.8052 | 0.0363 | ||||||||
| T4a/b | T3a/b | 1.1701 | 0.6918 | ||||||||
| pN-stage | pN+ | pN− | 1.8703 | 0.0841 | |||||||
| LI | LI+ | LI− | 2.9295 | 0.0009 | 2.6977 | 0.0027 | |||||
| VI | VI+ | VI− | 2.3559 | 0.0209 | |||||||
| TS | ≥3 cm | <3 cm | 1.0311 | 0.9274 | |||||||
Overall survival (OS); cancer-specific survival (CSS); disease-free survival (DFS); glycosyltransferase (GT); high gene expression is indicated by “+” and low gene expression by “−”; tumor stage (pT); lymph node metastasis present (pN+); lymph node metastasis absent (pN−); lymphatic vessel invasion present (LI+); lymphatic vessel invasion absent (LI−); blood vessel invasion present (VI+); blood vessel invasion absent (VI−); tumor size (TS); not significant (ns); significant p-values are displayed in bold.